Continuous Grouth of Brucella abortus in Mononuclear Phagocytes of Rats and Guinea Pigs.

Abstract

Continuous intracellular growth of virulent Brucella abortus organisms, within mononuclear cells of guinea pigs, by periodic transfer from tissue culture to tissue culture has been accomplished. Comparable continuous growth could not be accomplished using rat-monocyte cultures. Continuous transfers were unsuccessful in the case of rough avirulent organisms in guinea pig-and rat-monocyte cultures. The bearing of these observations upon host and species resistance have been discussed.