FAILURE OF DOPAMINE INFUSION TO SUPPRESS THE PLASMA PROLACTIN RESPONSE TO SULPIRIDE IN NORMAL AND HYPERPROLACTINEMIC SUBJECTS
- 1 October 1977
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 45 (4), 841-844
- https://doi.org/10.1210/jcem-45-4-841
Abstract
In eleven normal women dopamine infusion (5 μg/Kg/min) significantly lowered plasma prolactin levels but failed to suppress the PRL response to sulpiride (10 or 100 mg i.v.), while the same dose of dopamine was effective in abolishing the PRL response to TRH (200 μg i.v.). In four hyperprolactinemic women showing an impaired PRL response to sulpiride, dopamine infusion was effective both in lowering PRL circulating levels and in restoring an evident response to sulpiride. This finding suggests an impairment of endogenous dopamine activity in hyperprolactinemic amenorrhea.Keywords
This publication has 4 references indexed in Scilit:
- MECHANISM OF INCREASED PROLACTIN SECRETION BY SULPIRIDEJournal of Endocrinology, 1977
- Effects of Dopamine Infusion on Pituitary Hormone Secretion in Humans1Journal of Clinical Endocrinology & Metabolism, 1976
- EFFECT OF SULPIRIDE ON SERUM PROLACTIN LEVELS IN HUMANSJournal of Clinical Endocrinology & Metabolism, 1976
- Acute and Chronic Effects of Sulpiride on Serum Prolactin and Gonadotropin Levels in Castrated Male RatsExperimental Biology and Medicine, 1975