Characterization of Two Newly Recognized Rhinovirus Serotypes of Human Origin.

Abstract

Summary Two new viruses, 1505 and 8213, were recovered from the human oro-pharynx in two separate epidemiological studies. The viruses were found possess characteristics of agents in the rhinovirus subgroup of picornaviruses: small size (15-30 mμ), RNA core, ether stability, inactivation at pH 3.0. Both 1505 and 8213 viruses were tested by neutralization tests against 85 previously described rhinovirus serotypes and 11 possible candidate rhinoviruses, and both were found to be distinct antigenically from all ninety-six. Addendum; Following the completion of this study, the two rhinovirus strains were assigned serotype numbers by the participants in the WHO-NIAID Rhinovirus Collaborative Nomenclature Program. Rhinovirus strain 1505 was designated rhinovirus 48 and rhinovirus strain 8213 was designated rhinovirus 49.