Zimelidine: A therapeutic and pharmacokinetic study in depression
- 21 June 1979
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 63 (3), 199-202
- https://doi.org/10.1007/bf00433549
Abstract
Zimelidine, a bicyclic compound with a strong effect on the neuronal reuptake of 5-hydroxytryptamine and with weak anticholinergic actions, was evaluated for its antidepressant efficacy in a double-blind comparative trial with amitriptyline. In doses of 200 mg a day it was found to be as effective as 150 mg amitriptyline, but with significantly less subjective side-effects. The plasma concentration of zimelidine and its metabolite, norzimelidine, showed no significant correlation with therapeutic outcome.Keywords
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