Growth Inhibition of Sarcoma and Carcinoma Cells of Homozygous Origin

Abstract

Three sarcomas and one carcinoma, originating in homozygous mice, were tested for growth in isologous animals and various semi-isologous F₁ hybrids after inoculation of 10³ to 10⁵ cells. Findings indicated the existence of an "F₁ hybrid effect" for sarcomas and carcinomas, as previously described for lymphomas and normal hematopoietic cells, there being a lower tumor frequency and a longer latency period in the hybrids than in isologous mice.