In presenting a preliminary report of our experiences with the hypoglycemic treatment of the schizophrenic reactions, we wish to discuss briefly the methods of study employed as well as the actual results obtained in our small series of completed cases. Most of the writers in this field have recognized the great difficulty involved in the evaluation of therapeutic results, arising chiefly from the heterogeneity of the schizophrenic psychoses, from the conflicting statistics regarding the "natural" prognosis of these conditions, taken as a group, and from the lack of reliable prognostic criteria in the individual cases. If these factors, even in a large series, militate considerably against the validity of any purely statistical comparison between treated and untreated cases, it is apparent that in a small series such as ours a statistical evaluation would be worthless. We do not intend to imply that the value of Sakel's method cannot be demonstrated