ANTIMETASTATIC AND ANTI-TUMOR ACTIVITY OF A DERIVATIVE OF NEOCARZINOSTATIN - ORGANIC SOLVENT-SOLUBLE AND WATER-SOLUBLE POLYMER-CONJUGATED PROTEIN

Google Scholar
  • 1 January 1979
    • journal article
    • research article
    • Vol. 70 (5), 601-606
Abstract
A highly lymphotropic derivative of a proteinaceous antitumor agent, neocarzinostatin, was prepared by chemical conjugation of a water-soluble synthetic poly(maleic acid)-styrene oligomer. The derivative of 2.5 .times. 104 dalton exhibited a strong antitumor activity against [rat ascites tumor] AH109A and of [rat leukemia cells] DBLA-6 and antimetastatic activity against lymphatic metastatis of AH109A in rats. An increased lipophilicity and MW of the derivative appear to be responsible for its improvement as lymphotropic antimetastatic agent.