Epidermal Growth Factor Stimulates Growth Hormone Secretion from Superfused Rat Adenohypophyseal Fragments

Abstract
Epidermal growth factor (EGF) stimulated GH secretion from superfused rat adenohypophyseal fragments in a dose-related manner (8–50 ng/ml). Secretion of PRL or TSH was not affected by EGF at concentrations up to 50 ng/ml. These results indicate that EGF may be a specific secretagogue for GH in rats. (Endocrinology115: 556–558, 1984)