Inhibitory effect of somatostatin on gastric acid secretion and serum gastrin in dogs with and without duodenogastric reflux.
- 1 November 1980
- Vol. 21 (11), 996-1001
- https://doi.org/10.1136/gut.21.11.996
Abstract
The hypersecretion of gastric acid in response to pentagastrin, caused by duodenal reflux, was tested in dogs. An infusion of 0.25 .mu.g/kg per h resotred the raised responses seen in the reflux dogs to control levels. Somatostatin was a strong inhibitor of pentagastrin-stimulated acid secretion and of gastrin release, but it was a weak inhibitor of histamine. Somatostatin may have played a part in acid homeostasis.This publication has 13 references indexed in Scilit:
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