The diagnosis of acquired hemolytic anemia secondary to autoantibodies is being made with increasing frequency in recent years. In large part this is due to the recent availability of new technics for detecting this group of disorders, and for separating these cases from other varieties of hemolytic anemia, more particularly from the hemolytic blood disorders of congenital origin.1 In this regard the presence of a positive Coombs' test is generally considered to be of paramount importance in establishing the diagnosis of acquired hemolytic anemia.2 Included in this group of acquired hemolytic anemias with autoantibodies are those cases secondary to various