Activation of Oxidative Stress by Acute Glucose Fluctuations Compared With Sustained Chronic Hyperglycemia in Patients With Type 2 Diabetes

Abstract

Diabetes is characterized by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis.^1-4 Even though a large number of studies have investigated and compared the roles of the different factors that participate in diabetic vascular complications, an accurate assessment of their respective contributions is still difficult.^2,5,6 However, as demonstrated by many trials, microvascular and macrovascular complications are mainly^7,8 or partly^4,8 dependent on hyperglycemia.