The synergistic action of L‐glutamate and L‐aspartate at crustacean excitatory neuromuscular junctions.
- 30 June 1977
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 268 (3), 697-709
- https://doi.org/10.1113/jphysiol.1977.sp011877
Abstract
L-glutamate and L-aspartate simultaneously applied to the excitatory neuromuscular junctions of Maia squinado produce an increase in the conductance of the post-synaptic membrane much larger than the sum of conductance effects produced by the individual amino acids. An examination of the synaptic noise occurring during this synergistic action reveals that the elementary conductance events produced by aspartate are suppressed and that normal elementary conductance events produced by glutamate occur at an enormously increased rate. Aspartate caused this potentiation by inhibiting a system for transmitter inactivation in the region of the post-synaptic receptors, and this system under normal conditions prevents the access of externally applied glutamate to the synaptic receptors.This publication has 10 references indexed in Scilit:
- On the elementary conductance event produced by L‐glutamate and quanta of the natural transmitter at the neuromuscular junctions of Maia squinado.The Journal of Physiology, 1976
- The post-synaptic action of some putative excitatory transmitter substancesProceedings of the Royal Society of London. B. Biological Sciences, 1976
- Cooperative interaction of glutamate and aspartate with receptors in the neuromuscular excitatory membrane in walking limbs of the lobsterJournal of Neurobiology, 1975
- Glutamate and aspartate as mediators of neuromuscular excitation in the lobster.1975
- THREE-DIMENSIONAL ULTRASTRUCTURE OF THE CRAYFISH NEUROMUSCULAR APPARATUSThe Journal of cell biology, 1974
- Voltage clamp analysis of acetylcholine produced end‐plate current fluctuations at frog neuromuscular junctionThe Journal of Physiology, 1973
- The binding of acetylcholine to receptors and its removal from the synaptic cleftThe Journal of Physiology, 1973
- The statistical nature of the acetylcholine potential and its molecular componentsThe Journal of Physiology, 1972
- The dependence of glutamate uptake by crab nerve on external Na+ and K+Biochimica et Biophysica Acta (BBA) - Biomembranes, 1971