ROLE OF METAL IONS IN ENZYME SYSTEMS

Abstract

The role of metal ions in the action of various types of metalloenzymes [heme enzymes, Cu-enzymes, proteolytic enzymes, arginase, keto acid carboxylases, carbonic anhydrase, phosphatases, and phosphate-transferring enzymes] was reviewed in the light of some general considerations on the physical properties of metallic ions as they relate to metal ion specificities among different metalloenzymes, and the nature of the structural linkages between metal ions and pertinent organic and inorganic molecules. Not all phases of this general subject were covered nor could a complete compilation of the literature be made. Where possible, reference was made to a number of reviews and monographs which provided more complete documentation.