ULTRACENTRIFUGAL STUDIES OF REACTIONS OF RHEUMATOID FACTOR WITH NATIVE HUMAN GAMMAG-GLOBULIN
- 1 January 1966
- journal article
- research article
- Vol. 10 (6), 527-+
Abstract
Analytical ultracentrifugation has been employed in a study of the effect of pH on the dissociation of the 22S complexes formed in vitro between isolated rheumatoid factor and native human [gamma]G-globulin (prepared from autoiogous'' and isologous rheumatoid sera and from normal sera). The results indicate that rheumatoid factor has equal avidity for each of the [gamma]G-globulins tested irrespective of their source. The possibility that native human [gamma]G-globulin is a "haptenic" form of aggregated [gamma]G-globulin is discussed.This publication has 6 references indexed in Scilit:
- THE FORMATION AND PROPERTIES OF POLIOVIRUS NEUTRALIZING ANTIBODY1Acta Pathologica Microbiologica Scandinavica, 1965
- Demonstration of the Exposure of New Antigenic Determinants Following Antigen–antibody CombinationNature, 1965
- REACTIVITY OF RHEUMATOID FACTOR WITH HUMAN GAMMA G GLOBULIN1965
- Variations in Affinities of Antibodies during the Immune Response*Biochemistry, 1964
- Studies of the antibody nature of the rheumatoid factor: Reaction of the rheumatoid factor with human specific precipitates and with native human gamma globulinArthritis & Rheumatism, 1963
- The rheumatoid factorsJournal of Chronic Diseases, 1963