Participation of a Nonenzymatic Transformation in the Biosynthesis of Estrogens from Androgens
- 7 January 1977
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 195 (4273), 80-81
- https://doi.org/10.1126/science.831259
Abstract
The biosynthesis of estrogens from androgens proceeds via three enzymatic hydroxylations, of which the first two take place on the C-19 methyl group and convert it to aldehyde. The final and rate-determining hydroxylation occurs at the 2 beta position, and the product rapidly and nonenzymatically collapses to an estrogen.Keywords
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