CHROMOSOME 15 IN PRADER‐WILLI SYNDROME

Abstract

Nineteen children with the clinical features of Prader-Willi syndrome were karotyped, using routine Giemsa banding and high-resolution techniques. Chromosome abnormalities involving chromosome 15 were found in 10, entirely normal chromosomes in 5 and for the remaining 4 the findings were either equivocal or difficult to interpret. There was no clinical distinction between cases with and without the chromosome anomaly. Examination of 3 parents and a group of controls showed that the proximal end of the long arm of chromosome 15 may have a considerable degree of normal variation, which can make interpretation difficult.