ENZYMATIC SYNTHESIS OF SIALIC ACID 9-PHOSPHATES
- 1 July 1961
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 47 (7), 958-961
- https://doi.org/10.1073/pnas.47.7.958
Abstract
An enzyme (N-acylneuraminic acid 9-phosphate synthetase), isolated from pig submaxillary glands, catalyzes the following reaction: N-acyl-D-mannosamine 6-phosphate + phosphoenolpyruvate N-acylneuraminic acid 9-phosphate + Pi. Whether the N-acetyl- and N-glycolynlneuraminic acid 9-phosphates are formed by the same enzyme remains to be established as well as the possible relationship between these substances and the biosynthesis of nucleotides containing sialic acids.Keywords
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