The Pyelogram-Urea Washout Test

Abstract

RENAL-artery narrowing leading to decreased perfusion pressure may result in an exaggerated secretion of renin by the juxtaglomerular cells of the involved kidney,¹ with subsequent production of angiotensin leading to systemic hypertension. Because the measurement of renin and angiotensin is extremely difficult several indirect tests have been employed to facilitate the diagnosis of insufficiency of the renal artery. acid concentrations are increased in the urine from the involved kidney. Modern urographic contrast mediums are filtered by the glomerulus but are not reabsorbed by the tubules.⁴ Therefore, in patients with unilateral renal-artery insufficiency, increased water reabsorption without reabsorption of contrast material . . .