Mild Hemophilia Affecting Both Males and Females

Abstract

SYMPTOMATIC hemophilia in females, with clinical and laboratory data, has been rarely demonstrated, although cases of clinically apparent hemophilia in females who were assumed to be homozygous for the trait have been described.^{1 , 2} Detectable deficiencies, based on laboratory tests, in some heterozygous "carriers" of deficiencies of both antihemophilic factor (AHF, factor VIII) and plasma thromboplastin component (PTC, factor IX) have also been reported.^{3 4 5 6 7 8} On the other hand, both males and females may be affected by "vascular hemophilia" (Willebrand's disease, pseudohemophilia, angiohemophilia). It is uncertain whether the symptomatology in Willebrand's disease results from a vascular defect alone or from a reduced . . .