BILE ACIDS AND THEIR CHOLINE SALTS APPLIED TO THE INNER SURFACE OF THE ISOLATED COLON AND ILEUM OF THE GUINEA PIG

Abstract

Conjugated bile acids, desoxycholic and cholic acid, choline, and also the choline salts of these bile acids, exert analogous influences on the small and large isolated intestine of the guinea pig, when applied to the internal surface. Low doses always cause stimulation of the rhythmic movements. With higher doses, the tonus increases and tends to counteract the wave movements. This is expressed by slowing of the rate and later by decrease of the amplitude of the waves. Bile acids stimulate more the oscillatory movements; choline has a stronger influence on tonus increase. The choline salts of bile acids combine and moderate both effects. Among the bile acids, the conjugated natural acid mixture is of weakest action, cholic, stronger, and desoxycholic acid, strongest. While choline finally tends to produce spastic arrest of movements, the choline salts of bile acids mostly maintain a slow longitudinal and peristaltic movement even at high tonus. The small intestine more readily is subject to tonic arrest than the large intestine. Washing out of the treated prepn. decreases the tonus and establishes rhythmic movements, mostly of greater regularity, than is observed in the untreated gut. Prolonged washing leads to arrest in relaxation.