Liver Affection in Iron Overload Studied with Serum Ferritin and Serum Aminotransferases
- 12 January 1985
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 217 (1), 79-84
- https://doi.org/10.1111/j.0954-6820.1985.tb01638.x
Abstract
Liver dysfunction as measured by S-ALAT [serum alanine aminotransferase] activity was present in 72% of patients > 40 yr of age with HLA-related Fe overload [hemochromatoses] mainly detected by laboratory screening. Liver dysfunction was correlated to the amount of Fe stored (r = 0.54, P < 0.001). When Fe was removed by phlebotomy, liver function returned to normal. S-ALAT activity was closely correlated to serum ferritin concentration (r = 0.73, P < 0.001). Even a mild Fe excess can affect hepatocytes and result in increased levels of ferritin and aminotransferases in serum. Patients with "transaminitis" should be investigated for Fe overload.Keywords
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