DPY-26, a Link Between Dosage Compensation and Meiotic Chromosome Segregation in the Nematode
- 6 December 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 274 (5293), 1732-1736
- https://doi.org/10.1126/science.274.5293.1732
Abstract
The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome segregation. DPY-26 was shown to mediate both processes through its association with chromosomes. In somatic cells, DPY-26 associates specifically with hermaphrodite X chromosomes to reduce their transcript levels. In germ cells, DPY-26 associates with all meiotic chromosomes to mediate its role in chromosome segregation. The X-specific localization of DPY-26 requires two dosage compensation proteins (DPY-27 and DPY-30) and two proteins that coordinately control both sex determination and dosage compensation (SDC-2 and SDC-3).Keywords
This publication has 16 references indexed in Scilit:
- Sex-Specific Assembly of a Dosage Compensation Complex on the Nematode X ChromosomeScience, 1996
- VIVE LA DIFFÉRENCE: Males vs Females in Flies vs WormsAnnual Review of Genetics, 1996
- Equality for X ChromosomesScience, 1995
- SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family.Genes & Development, 1995
- Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.Genes & Development, 1995
- DPY-27: A chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosomeCell, 1994
- A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitroCell, 1994
- SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.The Journal of cell biology, 1993
- Independent domains of the Sdc-3 protein control sex determination and dosage compensation in C. elegansCell, 1993
- Generation of asymmetry and segregation of germ-line granules in early C. elegans embryosCell, 1983