Phenotypic Resistance to Amphotericin B in Candida albicans: the Role of Reduction

Abstract

Physiological studies of phenotypic resistance of amphotericin B in C. albicans were conducted. The 1st stage of phenotpic resistance can possibly be attributed to a reducible factor in the cell wall and the amount of this factor may increase during starvation, but the developed resistance is apparently determined by the degree of reduction of this factor. The evidence is not inconsistent with glutamate in the pool acting as a major source of reducing potential.