Mouse Antibody-Dependent Eosinophil and Macrophage Adherence and Damage to Schistosomula of Schistosoma Mansoni
- 31 January 1979
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 122 (2), 398-405
- https://doi.org/10.4049/jimmunol.122.2.398
Abstract
The effects of sera from S. mansoni-infected mice together with eosinophil- and macrophage-rich peritoneal exudate cells (PEC) on the schistosomula were examined in vitro. Adherence to and killing of the parasite by PEC is mediated through a complement-independent opsonizing IgG. Destruction of schistosomula was assessed morphologically and by evaluating their infectivity to normal mice. By using ferritin-labeled anti-mouse immunoglobulin, the antibody was localized on the surface of the schistosomula and at the cell-organism areas of contact. The serum antibody activity appears with the onset of egg production, does not correlate well with the duration of infection, and is relatively specific among schistosome species. Eosinophils and macrophages were demonstrated by electron microscopy to adhere firmly to the surface of the organisms; the latter cells were shown invading the schistosomula. Furthermore, depletion of eosinophils by prior incubation of PEC with monospecific anti-eosinophil serum blocked the early adherence phase, but a substantial part of PEC ability to kill the schistosomula was retained.This publication has 5 references indexed in Scilit:
- Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni.The Journal of Experimental Medicine, 1978
- Interaction between IgE complexes and macrophages in the rat: a new mechanism of macrophage activationEuropean Journal of Immunology, 1977
- Eosinophils and resistance to Trichinella spiralis.The Journal of Experimental Medicine, 1977
- Schistosoma mansoni: Immunoglobulins involved in passive immunization of laboratory miceExperimental Parasitology, 1977
- Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purieid eosinophils.The Journal of Experimental Medicine, 1977