Toxicology of vindesine (desacetyl vinblastine amide) in mice, rats, and dogs
- 30 April 1976
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 1 (5), 843-849
- https://doi.org/10.1080/15287397609529384
Abstract
Comparative acute intravenous toxicity studies of vinblastine sulfate (VLB), vincristine sulfate (VCR), and vindesine1 in mice and rats indicated that vindesine was more toxic than VLB and less toxic than VCR. Rats were able to tolerate larger repeated doses of vindesine than dogs. Rats given intravenous doses totaling 0.15 mg/kg‐wk vindesine for 3 months developed no remarkable signs of toxicity. Doses of 0.3 mg/kg‐wk or greater produced anorexia, depressed blood cell counts, atrophic intestinal mucosa, inhibition of spermatogenesis, extramedullary hematopoiesis, and infections. Dogs were given total weekly intravenous doses of 0.04, 0.08, 0.1, or 0.16 mg/kg vindesine for 3 months. The only observed effect in the two lower dose groups was inhibition of spermatogenesis. Groups receiving 0.1 or 0.16 mg/kg developed leukopenia, slight erythropenia, inhibition of spermatogenesis, focal skeletal muscle degeneration, elevated lactic dehydrogenase, and an increase in bone marrow myeloid: erythroid ratio. No evidence of functional or structural changes in neural tissues was found. The above effects are common to animals given VCR at lower doses and for a shorter test period. It is therefore concluded that vindesine is less toxic in animals than VCR.This publication has 10 references indexed in Scilit:
- Small bowel changes associated with vincristine sulfate treatment: An experimental study in the guinea pigCancer, 1974
- Neurotoxicity of Commonly Used Antineoplastic AgentsNew England Journal of Medicine, 1974
- Vincristine NeurotoxicityAnnals of Internal Medicine, 1974
- SYSTEMS OF MATERIAL TRANSPORT IN NERVE FIBERS (AXOPLASMIC TRANSPORT) RELATED TO NERVE FUNCTION AND TROPHIC CONTROL*Annals of the New York Academy of Sciences, 1974
- Vincristine neurotoxicity and abnormal secretion of antidiuretic hormoneArchives of Internal Medicine, 1973
- VINCRISTINE NEUROPATHYBrain, 1973
- The neuromyopathy of vincristine in the guinea pig: An electrophysiological and pathological studyJournal of the Neurological Sciences, 1970
- EFFECTS OF MITOTIC SPINDLE INHIBITORS ON NEUROTUBULES AND NEUROFILAMENTS IN ANTERIOR HORN CELLSThe Journal of cell biology, 1968
- VINCA ALKALOIDS - A NEW CLASS OF ONCOLYTIC AGENTS1963