Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 5 (6), 815-819
- https://doi.org/10.1093/carcin/5.6.815
Abstract
2-Amino-6-methyldipyrido[1,2-a:3',2' -d]imidazole and 2-aminodipyrido[1,2-a:3',2'-d]imidazole, potent mutagens from glutamic acid pyrolysate, were given orally to CDF1 mice of both sexes at concentrations of 0.05% in pellet diet. 2-Amino-3-methyl-9H-pyrido[2,3-b]indole and 2-amino-9H-pyrido[2,3-b]indole, potent mutagens from soybean globulin pyrolysate, were given to CDF1 mice of both sexes at concentrations of 0.08%. Hepatocellular carcinomas and hemangio-endothelial sarcomas in the brown adipose tissue were induced in high incidence by all these compounds.This publication has 9 references indexed in Scilit:
- INDUCTION OF CANCERS IN THE INTESTINE, LIVER AND VARIOUS OTHER ORGANS OF RATS BY FEEDING MUTAGENS FROM GLUTAMIC-ACID PYROLYSATE1984
- Mutagenic activity of heterocyclic amines in Chinese hamster lung cells with diphtheria toxin resistance as a markerMutation Research/Genetic Toxicology, 1983
- High incidence of angiosarcomas in brown-fat tissue and livers of mice fed sterigmatocystinFood and Chemical Toxicology, 1982
- Determination of mutagens, amino-α-carbolines in grilled foods and cigarette smoke condensateCancer Letters, 1981
- Amino-α-carbolines as mutagenic agents in cigarette smoke condensateCancer Letters, 1980
- Metabolic activation of a mutagen, 2-amino-6-methyldipyrido-[1,2-a:3′,2′-d]imidazole. Identification of 2-hydroxyamino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole and its reaction with DNABiochemical and Biophysical Research Communications, 1980
- Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulinBiochemical and Biophysical Research Communications, 1978
- Mutagenicities of protein pyrolysatesCancer Letters, 1977
- Mutagenicities of smoke condensates and the charred surface of fish and meatCancer Letters, 1977