Der Anteil von Histamin an der anaphylaktischen und der durch einen chemischen Histaminfreisetzer hervorgerufenen vasculären Hautreaktion

Abstract

A compara-tive quantitative investigation was carried out on the inhibitory action of mepyramine as a specific and of atropine as a non-specific anti-histamine by means of the "cutaneous reaction" in the guinea-pig. This reaction is characterized by increased local vascular permeability and is evoked by an antigen-antibody reaction, compound 48/80 (formaldehyde condensation product of p-methoxy-N-methylphenethylamine) and injected histamine. Liberated histamine is responsible only in part for the cutaneous anaphylactic reaction. The relative participation of a non-histamine-like component depends on the antigen dose. Within the range of antigen doses investigated, the liberated histamine barely increased with antigen dose, whereas the participation of a non-histamine-like effective component increased. In cases where cutaneous reactions were produced by the histamine liberator, compound 48/80, the participation of a non-histamine-like component was relatively larger than in cutaneous anaphylactic reactions. The non-histamine-like effective agent seemed to be qualitatively different in both reactions.