Significance of HLA and blood‐group incompatibility in spontaneous abortion
- 1 June 1976
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 9 (6), 575-582
- https://doi.org/10.1111/j.1399-0004.1976.tb01615.x
Abstract
The frequencies of antigen-incompatible matings within the HLA [human histocompatability antigen], Rhesus, Lutheran (Lu), MN, S. Lewis, Kell, P and Duffy systems were studied in 481 parents of karyotyped spontaneous abortuses. The results were compared with the calculated mating frequencies in control samples consisting of 1197 (HLA) and 12,123 (the remaining 8 systems) individuals, respectively. The only significant difference observed at the 5% level was an increased frequency of matings in which the mother was Lu (a+) and had a karyotypically abnormal abortus. Antigen incompatibility between the parents within the 9 systems studied is not important in the etiology of early spontaneous abortion or causative in the origin of chromosome anomalies in the fetus.Keywords
This publication has 8 references indexed in Scilit:
- Aetiology of Spontaneous AbortionActa Obstetricia et Gynecologica Scandinavica, 1976
- Materno‐fetal ABO incompatibility as a cause of spontaneous abortionClinical Genetics, 1975
- Cytotoxic HL‐A Antibodies: Immunoglobulin ClassificationTissue Antigens, 1971
- MATERNAL-FETAL INCOMPATIBILITYTransplantation, 1970
- A Comparative Observation of the Presence of Anti‐Tja‐like Hemolysins in Relation to Obstetric History, Distribution of the Various Blood Groups and the Occurrence of Immune Anti‐A or Anti‐B Hemolysins Among Aborters and NonabortersTransfusion, 1965
- BLOOD GROUPS IN ABORTION AND STERILITY*Annals of Human Genetics, 1955
- The Rare Human Isoagglutinin Anti-Tj a and Habitual AbortionScience, 1954