Lipodystrophic Muscular Hypertrophy

Abstract

A girl of 2 years and 10 months with a number of unusual features including lipodystrophy, generalized muscular hypertrophy, hepatomegaly with biochemical and histological evidence of disordered function, enlargement of the hands, feet and clitoris, abdominal protuberance and a lowered concentration of glucose in the blood, is described. There are reports in the literature of patients who appear to have the same syndrome in either "congenital" or "acquired" form. It is suggested that the syndrome results from hormonal action, possibly from the excessive secretion of a specific pituitary hormone. "Lipodystrophic muscular hypertrophy" is proposed as the name for the syndrome.