The Effects of Central Adiposity on Growth Hormone (GH) Response to GH-Releasing Hormone-Arginine Stimulation Testing in Men
Open Access
- 1 November 2008
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 93 (11), 4254-4260
- https://doi.org/10.1210/jc.2008-1333
Abstract
Context: The relative contribution of central adiposity vs. weight on GH response to stimulation testing in obesity is not known. Objective: We aimed to assess the contribution of weight and specific measures of central and peripheral adiposity to GH response to GHRH-arginine testing in lean, overweight, and obese men. Design: A total of 75 men [mean age, 44.3 ± 1.1 yr; body mass index (BMI), 28.8 ± 0.7 kg/m2] were investigated. Subjects were classified as lean (BMI < 25 kg/m2; n = 23), overweight (BMI ≥ 25 and 2; n = 28), or obese (BMI ≥ 30 kg/m2; n = 24). Subjects were also stratified by waist circumference (WC) (Results: Peak stimulated GH was 36.4 ± 5.4, 16.6 ± 2.9, and 7.6 ± 0.9 μg/liter among lean, overweight, and obese subjects, respectively (P < 0.001 for all comparisons). Peak stimulated GH was 26.9 ± 3.4 μg/liter among subjects with WC less than 102 cm compared to 7.9 ± 0.9 μg/liter among subjects with WC of 102 cm or greater (P < 0.0001). Separate multivariate models using anthropometric, DEXA, and CT-derived measures of central adiposity demonstrated strong associations between peak stimulated GH and measures of central adiposity including WC, trunk fat by DEXA, and visceral adiposity by CT, controlling for age, BMI, and more general measures of adiposity. WC was independently associated with peak GH response to GHRH-arginine in a model including age, BMI, and hip circumference. In this model, BMI was no longer significant, and peak GH was reduced 1.02 μg/liter for each 1 cm increase in WC (P = 0.02). Conclusions: GH response to GHRH-arginine testing is reduced in both overweight and obese subjects and negatively associated with indices of central abdominal obesity including WC, trunk fat, and visceral adipose tissue. The use of waist circumference, as a surrogate for central adiposity, adds predictive information to the determination of GH response, independent of BMI.Keywords
This publication has 29 references indexed in Scilit:
- Body Mass Index Determines Evoked Growth Hormone (GH) Responsiveness in Normal Healthy Male Subjects: Diagnostic Caveat for Adult GH DeficiencyJournal of Clinical Endocrinology & Metabolism, 2004
- Sexual Dimorphism of Growth Hormone (GH) Regulation in Humans: Endogenous GH-Releasing Hormone Maintains Basal GH in Women But Not in MenJournal of Clinical Endocrinology & Metabolism, 2003
- Comparison between insulin tolerance test, growth hormone (GH)-releasing hormone (GHRH), GHRH plus acipimox and GHRH plus GH-releasing peptide-6 for the diagnosis of adult GH deficiency in normal subjects, obese and hypopituitary patientsActa Endocrinologica, 2003
- Low Amplitude and Disorderly Spontaneous Growth Hormone Release in Obese Women with or without Polycystic Ovary SyndromeJournal of Clinical Endocrinology & Metabolism, 2002
- Altered Neuroregulation of GH Secretion in Viscerally Obese Premenopausal WomenJournal of Clinical Endocrinology & Metabolism, 2001
- Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)JAMA, 2001
- Assessment of Growth Hormone Dynamics in Human Immunodeficiency Virus-Related Lipodystrophy1Journal of Clinical Endocrinology & Metabolism, 2001
- IMPAIRED GROWTH HORMONE RESPONSE TO GROWTH HORMONE RELEASING FACTOR AND INSULIN‐HYPOGLYCAEMIA IN OBESITYClinical Endocrinology, 1985
- Impaired Growth Hormone Responses to Growth Hormone–Releasing Factor in ObesityNew England Journal of Medicine, 1984
- Effect of L-Dopa on Growth Hormone, Glucose, Insulin, and Cortisol Response in Obese SubjectsExperimental and Clinical Endocrinology & Diabetes, 1983