STUDIES ON HUMAN PROTEINURIA. II. SOME CHARACTERISTICS OF THE GAMMA GLOBULINS EXCRETED IN NORMAL, EXERCISE, POSTURAL, AND NEPHROTIC PROTEINURIA*

Abstract

The proteins excreted in "normal" exercise, postural, and nephrotic urines were studied by immuno-electrophoresis to determine the nature of the [gamma]-globulins. In contrast to the single precipitin line developed by the [gamma]-globulin in normal serum and postural proteinuria, double or triple lines or lines in series are formed by the [gamma]-globulins in the other three types of proteinuria. The findings suggest that, with respect to multiple bands, the [gamma]-globulins are excreted as fragments of small size, that exercise proteinuria may be an accentuation of the process responsible for normal proteinuria, and that relatively large amounts of the [gamma]-globulin fragments may be excreted in certain cases of nephrotic syndrome.