Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma
Open Access
- 4 February 1999
- journal article
- research article
- Published by Springer Nature in Oncogene
- Vol. 18 (5), 1205-1208
- https://doi.org/10.1038/sj.onc.1202416
Abstract
Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.Keywords
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