Comparative in vitro Activity of Three New Quinolone Antibiotics against Recent Clinical Isolates
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Infectious Diseases
- Vol. 17 (1), 91-94
- https://doi.org/10.3109/00365548509070426
Abstract
New orally absorbable quinolone derivatives, ciprofloxacin, norfloxacin, and ofloxacin demonstrated excellent activity in vitro against clinical isolates of Escherichia coli, Klebsiella, Enterobacter, Proteus mirabilis, Proteus sp. indole-positive, Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Streptococcus pyogenes and enterococci. None of the 3 drugs was more than moderately effective against Bacteroides fragilis. Ciprofloxacin was 2–4 times more effective against most gram-negative strains than was either norfloxacin or ofloxacin, and was also the most effective against gram-positive strains, though the difference was less marked. Ciprofloxacin and ofloxacin were almost equally effective against S. aureus. Results with agar and with broth were comparable. The activities of all 3 drugs were essentially independent of inoculum size, as the MIC values increased less than one dilution step when the inoculum was increased from 103 to 106. The new quinolone derivatives would appear to be promising alternatives to injectable drugs such as the aminoglycosides and cephalosporins.This publication has 17 references indexed in Scilit:
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