Ambulatory blood pressure 16-26 years after the first urinary tract infection in childhood

Abstract

To evaluate blood pressure in a population- based cohort with urographic renal scarring after childhood urinary tract infection. Follow-up investigation 16–26 years after the first recognized urinary tract infection. University out-patient clinic for children with urinary infections serving the local area. From the original cohort of 1221 consecutive children with first urinary tract infection diagnosed during 1970–1979, 57 of 68 with non-obstructive renal scarring participated as well as 51 matched subjects without scarring. 24 h ambulatory blood pressure. Acceptable blood pressure monitorings were obtained from 53 individuals with and 47 without scarring. There were no significant differences between the two groups even when only patients with the most extensive scarring (individual kidney clearance 2 This study demonstrates a low risk of hypertension two decades after childhood urinary tract infection. It should be stressed that the patients with renal scarring were under close supervision throughout childhood. Those with scarring had higher concentrations of atrial natriuretic protein which might indicate a counter-regulation mechanism.