Morphologic development of fetal rabbit lung and its acceleration with cortisol.
- 1 August 1971
- journal article
- Vol. 64 (2), 423-42
Abstract
The influence of cortisol on the maturation of fetal lungs of rabbits has been studied. The normal developmental pattern of the various lobes is also documented and it is shown that there is a definite sequence of maturation among the five lobes of the lung. At a given gestational age, both upper lobes are consistently most mature. The right middle lobe is somewhat less mature while right and left lower lobes are least mature. The difference in the rate of maturation between the most advanced right apex and the least advanced base of lower lobes is as much as 1(1/2) days out of a total gestation of 30 days. Cortisol, injected into the fetuses 2 days prior to delivery, accelerated the overall maturation of the lung by about 1(1/2) days. The maturation of the type II epithelial cells also was accelerated and their inclusion bodies were more numerous than those of the controls. As reported elsewhere, prematurely delivered cortisol-injected rabbits of 26 to 28 days' gestation are more viable, breathe better and their lungs are better aerated when compared with control littermates. The surface activity of the alveolar lining of these animals is greater than that of the controls as indicated by higher ratios of bubble stability. These findings are apparently the results of accelerated maturation of the type II alveolar epithelial cells, which contain surfactant or its precursors as inclusions within the cytoplasm.This publication has 16 references indexed in Scilit:
- Mucopolysaccharide in the pulmonary alveolus. II. Electron microscopic observations.1970
- The Biochemical Development of Surface Activity in Mammalian Lung: II. The Biosynthesis of Phospholipids in the Lung of the Developing Rabbit Fetus and NewbornPediatric Research, 1967
- [Action of the adrenal cortex on the glycogen level of the heart in the rat fetus and the newborn rat].1966
- Factors affecting pulmonary surface properties in the foetal lamb.1965
- THE EFFECT OF IMMATURITY AND PRENATAL ASPHYXIA ON THE LUNGS AND PULMONARY FUNCTION OF NEWBORN LAMBS: THE EXPERIMENTAL PRODUCTION OF RESPIRATORY DISTRESSPediatrics, 1965
- Correlation of glucocorticoid-induced synthesis of hepatic gluconeogenic enzymes with amino acid level and RNA metabolismLife Sciences, 1964
- Stimulation of RNA-polymerase activity in rat liver by cortisolLife Sciences, 1964
- CYTOCHEMISTRY AND ELECTRON MICROSCOPYThe Journal of cell biology, 1963
- Increased liver glucose-6-phosphatase activity after cortisone administrationBiochimica et Biophysica Acta, 1955
- Properties, Function and Origin of the Alveolar Lining LayerNature, 1955