Clinical course in migraine
- 9 September 2008
- journal article
- review article
- Published by Wolters Kluwer Health in Neurology
- Vol. 71 (11), 848-855
- https://doi.org/10.1212/01.wnl.0000325565.63526.d2
Abstract
Migraine is currently conceptualized as a chronic disease with episodic manifestations, with attacks that increase in frequency in a subgroup (migraine transformation or progression). Transformation of migraine may be subdivided in three partially overlapping forms, although research in this area is still in infancy, and evidence is sometimes weak. Typically, transformation refers to increases in attack frequency over time leading to chronic migraine; this process is termed clinical transformation. Additionally, in some patients with migraine, physiologic changes in the CNS manifest themselves through alterations in nociceptive thresholds (allodynia) and alterations in pain pathways (physiologic transformation). Finally, in some individuals, definitive brain lesions including stroke and deep white matter lesions emerge (anatomic transformation). Herein we discuss the evidence that migraine may transform and then consider potential mechanisms as well as risk factors. We close with a brief discussion of clinical strategies that arise based on this perspective on migraine.Keywords
This publication has 50 references indexed in Scilit:
- Prevalence and characteristics of allodynia in headache sufferersNeurology, 2008
- Improved Identification of Allodynic Migraine Patients Using a QuestionnaireCephalalgia, 2007
- Cutaneous Allodynia in Transformed Migraine PatientsHeadache: The Journal of Head and Face Pain, 2007
- Chronic disorders with episodic manifestations: focus on epilepsy and migraineThe Lancet Neurology, 2006
- Migraine and MTHFR C677T genotype in a population‐based sampleAnnals of Neurology, 2005
- Transformed Migraine and Medication Overuse in a Tertiary Headache Centre — Clinical Characteristics and Treatment OutcomesCephalalgia, 2004
- Comorbidity of Depressive and Anxiety Disorders in Chronic Daily Headache and Its SubtypesHeadache: The Journal of Head and Face Pain, 2000
- An association between migraine and cutaneous allodyniaAnnals of Neurology, 2000
- Familial risk of migraine: A population‐based studyAnnals of Neurology, 1997
- OBSERVATIONS ON 500 CASES OF MIGRAINE AND ALLIED VASCULAR HEADACHEJournal of Neurology, Neurosurgery & Psychiatry, 1960