Acquired Circulating Anticoagulants in Systemic "Collagen Disease"
Open Access
- 1 July 1955
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 10 (7), 691-706
- https://doi.org/10.1182/blood.v10.7.691.691
Abstract
1. A circulating anticoagulant was demonstrated in three patients with "collagen disease." In all cases it was associated with a false positive blood serology and a four plus cephalin cholesterol flocculation. 2. In one instance, the anticoagulant was transferred to a newborn infant where it persisted for seven weeks. The infant also demonstrated the abnormal serologic and turbidimetric tests during the first six months of life. 3. The anticoagulant probably acted as anti-thromboplastin. 4. The occurrence of a clotting inhibitor in association with other manifestations of hypersensitivity and its transplacental transfer strongly suggest that the mechanism of development is immunologic in type. 5. This study included a total of thirty patients with lupus erythematosus disseminatus and associated conditions conventionally grouped under the term "collagen disease." The incidence of circulating anticoagulants was 10 per cent.Keywords
This publication has 7 references indexed in Scilit:
- THE RELATIVE INCIDENCE OF ANTI-HEMOPHILIC GLOBULIN (AHG), PLASMA THROMBOPLASTIN COMPONENT (PTC), AND PLASMA THROMBOPLASTIN ANTECEDENT (PTA) DEFICIENCY - A STUDY OF 55 CASES1954
- Hyperglobulinemia as the Cause of Hemophilia-like DiseaseBlood, 1953
- CONGENITAL FAMILIAL DEFICIENCY OF THE STABLE PROTHROMBIN CONVERSION FACTOR - RESTUDY OF CASE ORIGINALLY REPORTED AS IDIOPATHIC HYPOPROTHROMBINEMIA1953
- EFFECT OF ANTIHEMOPHILIC FACTOR ON ONE-STAGE CLOTTING TESTS - A PRESUMPTIVE TEST FOR HEMOPHILIA AND A SIMPLE ONE-STAGE ANTIHEMOPHILIC FACTOR ASSAY PROCEDURE1953
- Idiopathic Hypoprothrombinemia Associated with Hemorrhagic Diathesis, and the Effect of Vitamin KBlood, 1951
- CIRCULATING ANTICOAGULANT AS A CAUSE OF HEMORRHAGIC DIATHESIS IN MAN1948
- SERUM PROTEIN FRACTIONATION: A COMPARISON OF SODIUM SULFATE PRECIPITATION AND ELECTROPHORESISJournal of Biological Chemistry, 1947