Single and multiple dose pharmacokinetics of pindolol
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 13 (1), 13-16
- https://doi.org/10.1007/bf00606675
Abstract
The pharmacokinetics of pindolol were studied in six healthy individuals following a single 10 mg dose (SD) and multiple (5 mg tid over 6 days) doses (MD). The plasma elimination half-life was identical after SD (4.7±0,8 h) and MD (4.1±1.1 h). Steady state plasma concentrations were reached after 36 h and remained stable thereafter. The variation in steady state concentrations was small in each individual and also between individuals. The steady state concentration of pindolol can be predicted from the pharmacokinetic data obtained after a single dose. The results of the present study suggest that the disposition of pindolol is linear over the concentration range studied.Keywords
This publication has 18 references indexed in Scilit:
- Altered Hepatic Blood Flow and Drug Disposition1Clinical Pharmacokinetics, 1976
- Propranolol Disposition in Chronic Liver DiseaseClinical Pharmacokinetics, 1976
- Clinical Pharmacokinetics of β-Adrenoreceptor Blocking DrugsClinical Pharmacokinetics, 1976
- Clinical pharmacology of propranolol.Circulation, 1975
- Combined pharmacokinetic and pharmacodynamic studies in man of the adrenergic β1‐receptor antagonist metoprolol *Acta Pharmacologica et Toxicologica, 1975
- Combined pharmacokinetic and pharmacodynamic studies on alprenolol and 4-hydroxy-alprenolol in manLife Sciences, 1974
- Pharmacokinetic Properties of the ??-Adrenergic Receptor Blocking DrugsDrugs, 1974
- The Disposition of PropranololPharmacology, 1972
- The Disposition of PropranololPharmacology, 1972
- A method for the fluorimetric determination of 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole (LB 46), aβ-blocking agent, in plasma and urineCellular and Molecular Life Sciences, 1969