Canine hydrophobic surfactant polypeptide SP‐C A lipopeptide with one thioester‐linked palmitoyl group
- 9 April 1991
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 281 (1-2), 119-122
- https://doi.org/10.1016/0014-5793(91)80373-b
Abstract
The amino acid sequence and the posttranslational modification of the hydrophobic surfactant polypeptide SP-C from canine, rabbit and bovine lungs were established by direct sequence analysis and plasma-desorption time-of-flight mass spectrometry. The results reveal that canine SP-C has only one cysteine residue which, however, is palmitoylated, like the two Cys residues in other characterized SP-C molecules. In addition, canine SP-C is N-terminally truncated, with only 34 amino acid residues in its longest form. Thus, SP-C molecules can apparently vary to some extent in the N-terminal lipid modified part, whereas the extremely hydrophobic middle and C-terminal parts are well conserved.Keywords
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