Effects of bilateral auditory cortex ablation on behavior and unit activity in rat inferior colliculus during differential conditioning
- 1 May 1978
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 41 (3), 705-715
- https://doi.org/10.1152/jn.1978.41.3.705
Abstract
The development of both behavioral responses and short-latency responses of inferior colliculus neurons to tone pips was studied in normal rats and rats with bilateral ablation of auditory cortex during a differential conditioning experiment. Behavior measured was the development of a differential movement during the 1 s interval between the onset of the tone CS+ [positive conditioned stimulus] and the food pellet US [unconditioned stimulus]. Some animals with small lesions developed this behavior, but no animal with large lesions did so. Unit responses during the period 5-11 ms after stimulus onset were measured before and during conditioning. A large effect of the lesions on the variability of the background firing rates of neurons during conditioning but not during pseudoconditioning was discussed. In normal animals an approximately equal number of units showed background increases and decreases during conditioning. In the lesioned animals there were more background increases and almost no background decreases during conditioning. The idea that during the learning of such a discrimination, a nonspecific activation from noncortical structures is selectively antagonized by cortical efferents was presented.This publication has 10 references indexed in Scilit:
- Conditioned stimulus as a determinant of the form of the Pavlovian conditioned response.Journal of Experimental Psychology: Animal Behavior Processes, 1977
- Effects of unilateral ablation of auditory cortex on monaural cat's ability to localize soundJournal of Neurophysiology, 1977
- Learning centers of rat brain mapped by measuring latencies of conditioned unit responses.Journal of Neurophysiology, 1972
- Interrelationships of the Visual Cortex and Superior Colliculus in the CatNature, 1965
- NEURONAL ARCHITECTURE OF MEDIAL GENICULATE BODY OF CAT1964
- TONAL DISCRIMINATION AFTER ABLATION OF AUDITORY CORTEXJournal of Neurophysiology, 1962
- Suppression of Acoustic Input by Thalamic Stimulation.Experimental Biology and Medicine, 1958
- ABLATION OF TEMPORAL CORTEX AND DISCRIMINATION OF AUDITORY PATTERNSJournal of Neurophysiology, 1957
- CENTRAL INFLUENCES ON SPINAL AFFERENT CONDUCTIONJournal of Neurophysiology, 1954
- EFFECT OF DESTROYING THREE LOCALIZED CEREBRAL CORTICAL AREAS FOR SOUND ON CORRECT CONDITIONED DIFFERENTIAL RESPONSES OF THE DOG'S FORELEGAmerican Journal of Physiology-Legacy Content, 1945