Pallidal GABA and chorea in Huntington's disease
- 1 October 1990
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 81 (3), 241-246
- https://doi.org/10.1007/bf01245046
Abstract
Neurochemical correlates of chorea in Huntington's disease were studied using striatal and pallidal tissue taken post mortem from patients with mild and severe chorea. While GABA was decreased in all these areas in Huntington's disease, patients with mild chorea had significantly less GABA in the medial pallidum than did those with severe chorea. There was no relationship between the degree of chorea and concentrations of dopamine or its metabolite. Thus the chorea of Huntington's disease may relate to the balance of residual GABAergic innervation between specific areas of the basal ganglia, consistent with primate models of dyskinesias.Keywords
This publication has 14 references indexed in Scilit:
- CHOREA AND MYOCLONUS IN THE MONKEY INDUCED BY GAMMA-AMINOBUTYRIC ACID ANTAGONISM IN THE LENTIFORM COMPLEXBrain, 1988
- Neurotransmitters, receptors and neuropeptides in post‐mortem brains of chronic schizophrenic patientsActa Psychiatrica Scandinavica, 1988
- Decreased glutamic acid and increased 5-hydroxytryptamine in Huntington's disease brainNeuroscience Letters, 1987
- Striatal dopamine and homovanillic acid in Huntington's DiseaseJournal of Neural Transmission, 1986
- The neurochemistry of Huntington's choreaTrends in Neurosciences, 1981
- Postmortem Changes of Amino Compounds in Human and Rat BrainJournal of Neurochemistry, 1981
- NEUROCHEMICAL ALTERATIONS IN HUNTINGTON'S CHOREABrain, 1980
- DIFFERENTIAL EFFECTS OF AGONAL STATUS ON MEASUREMENTS OF GABA AND GLUTAMATE DECARBOXYLASE IN HUMAN POST‐MORTEM BRAIN TISSUE FROM CONTROL AND HUNTINGTON'S CHOREA SUBJECTSJournal of Neurochemistry, 1979
- AN ANALYSIS OF FACTORS INFLUENCING MEASUREMENTS OF DOPAMINE, NORADRENALINE, GLUTAMATEDECARBOXYLASE AND CHOLINE ACETYLASE IN HUMAN POST-MORTEM BRAIN TISSUEBrain, 1979
- Huntington's ChoreaNew England Journal of Medicine, 1973