A Silenced Plasmodium falciparum var Promoter Can Be Activated In Vivo through Spontaneous Deletion of a Silencing Element in the Intron
Open Access
- 1 February 2005
- journal article
- Published by American Society for Microbiology in Eukaryotic Cell
- Vol. 4 (2), 490-492
- https://doi.org/10.1128/ec.4.2.490-492.2005
Abstract
Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes.Keywords
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