THE EFFECT OF GOSSYPOL ON ATPASE ACTIVITY OF THE KIDNEY

Abstract

Results showed no change in the activity of ATPase of the renal cortex of rats administered gossypol [an antifertility agent] for 1/2 yr. Na+, K+-ATPase activity of the cellular membrane of the renal cortex of guinea pigs fed gossypol for 5 or 9 wk was significantly altered. It was possible to diminish or delay the inhibition by allowing the guinea pigs a K-rich diet ad lib. In vitro, gossypol significantly inhibited the activity of ATPase of the brain and kidney of rats and guinea pigs uncompetitively. The inhibition of the ATPase of human fetus kidney was of a mixed type.