Head-to-tail coupling of 1,2,3,4-tetrahydro-7-hydroxy-1-(4-hydroxy-phenethyl)-6-methoxy-2-methylisoquinoline by enzymic phenolic oxidation

Abstract

Head-to-tail coupling of 1,2,3,4-tetrahydro-7-hydroxy-1-(4-hydroxyphenethyl)-6-methoxy-2-methylisoquinoline (II) by enzymic phenolic oxidation has been accomplished to give the expected promelanthioidine (I).