Phosphorylation/Cytoplasmic Localization of p21Cip1/WAF1 Is Associated with HER2/ neu Overexpression and Provides a Novel Combination Predictor for Poor Prognosis in Breast Cancer Patients
Open Access
- 1 June 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 10 (11), 3815-3824
- https://doi.org/10.1158/1078-0432.ccr-03-0527
Abstract
Purpose: The peripheral benzodiazepine receptor (PBR) expression has been shown dramatically increased in neoplastic tissues and tumor cell lines originated from ovary, liver, colon, breast, or brain relative to untransformed tissues. Its expression has been also associated with tumor progression and aggressiveness. To explore whether PBR expression level could be of prognostic value in invasive breast cancer, we studied a series of 117 patients who underwent surgery for primary breast carcinomas and were followed-up for 8 years.Keywords
This publication has 27 references indexed in Scilit:
- Sustained Activation of the JNK Cascade and Rapamycin-Induced Apoptosis Are Suppressed by p53/p21Cip1Molecular Cell, 2003
- Flow cytometry and quantitative immunohistochemical study of cell cycle regulation proteins in invasive breast carcinomaCancer, 2003
- p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosisJournal of Clinical Pathology, 2003
- AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell SurvivalJournal of Biological Chemistry, 2002
- Subcellular localisation of cyclin B, Cdc2 and p21WAF1/CIP1 in breast cancerEuropean Journal Of Cancer, 2001
- HER-2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-κB PathwayJournal of Biological Chemistry, 2000
- Regulation of Cell Death Protease Caspase-9 by PhosphorylationScience, 1998
- Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cellsOncogene, 1998
- Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase AktScience, 1997
- Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu OncogeneScience, 1987