Natural Antibodies to Human Retrovirus HTLV in a Cluster of Japanese Patients with Adult T Cell Leukemia
- 19 February 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4535), 975-978
- https://doi.org/10.1126/science.6760397
Abstract
Human T cell lymphoma leukemia virus (HTLV) is a human retrovirus (RNA tumor virus) that was originally isolated from a few patients with leukemias or lymphomas involving mature T lymphocytes. Here we report that the serum of Japanese patients with adult T cell leukemia, but not the serum of tested normal donors, contains high titers of antibodies to HTLV. These observations, together with data from Japan showing that adult T cell leukemia is endemic in southwest Japan, suggest that HTLV is involved in a subtype of human T cell malignancy, including Japanese adult T cell leukemia.This publication has 13 references indexed in Scilit:
- Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in JapanProceedings of the National Academy of Sciences, 1982
- Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sézary T-cell leukaemiaNature, 1981
- Antibodies in human sera reactive against an internal structural protein of human T-cell lymphoma virusNature, 1981
- Natural antibodies to the human T cell lymphoma virus in patients with cutaneous T cell lymphomas.The Journal of Experimental Medicine, 1981
- Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell lineVirology, 1981
- Adult T-cell leukemia in Japan: An ultrastructural studyCancer, 1981
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980
- Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.The Journal of Experimental Medicine, 1980
- Leukæmia in the Cat: Transmission Experiments with Leukæmia (Lymphosarcoma)Nature, 1964
- "Spontaneous" Leukemia Developing in G3H Mice Following Inoculation, In Infancy, with AK-Emkemic.Experimental Biology and Medicine, 1951