Comparison of Effects of Estetrol and Tamoxifen with Those of Estriol and Estradiol on the Immature Rat Uterus1
- 1 May 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 22 (4), 913-926
- https://doi.org/10.1095/biolreprod22.4.913
Abstract
The estrogenic effects on this immature rat uterus of estetrol [1,3,5(10)-estratriene-3,15α, 16α, 17β-tetrol] (E4), a major metabolite of placental estrogens in the human fetus, and of tamoxifen (TAM), an antiestrogen, were compared with those of estradiol (E2) and estriol (E3). The compounds were injected s.c. daily, for 3 days, into 22- or 23-day-old Sprague-Dawley rats at a dose of 50 µg/100 g BW of E4 or TAM, and 1 µg/100 g BW of E2 or E3. Tissue was collected 24 to 27 h after the third injection.This publication has 17 references indexed in Scilit:
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