Association of Wilms's Tumor with Aniridia, Hemihypertrophy and Other Congenital Malformations

Abstract

WHEN, through epidemiologic study of persons or families, diseases are found to be associated, the opportunities for determining their etiology may be very much increased. The association of leukemia and mongolism¹ is an example. An accumulation of case reports in the past decade suggests a link between another childhood cancer, Wilms's tumor, and a rare congenital defect, total hemihypertrophy.^{2 3 4 5 6 7 8} In addition, isolated cases of Wilms's tumor in horseshoe kidneys have been reported.⁹ The purpose of this presentation is to define more fully the relation between Wilms's tumor and congenital defects by study of the diagnoses contained in the medical records . . .