Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT
- 1 March 1985
- journal article
- Published by Springer Science and Business Media LLC in Journal of Neural Transmission
- Vol. 61 (1-2), 131-135
- https://doi.org/10.1007/bf01253058
Abstract
The potent, centrally acting 5-HT receptor agonist 8-OH-DPAT was shown to induce a clearcut hypothermic response in naive and PCPA-pretreated conscious rats, maintained at 22 °C. PCPA pretreatment decreased the threshold dose of 8-OH-DPAT required to cause hypothermia, indicating that a sensitisation of 5-HT-receptor dependent mechanisms was involved. The results are discussed with reference to recent 5-HT receptor subclassification. It is suggested that body temperature measurements in the rat might provide a simplein vivo physiological means of studying central serotoninergic mechanisms, including 5-HT receptor sensitivity modification.Keywords
This publication has 6 references indexed in Scilit:
- DIFFERENTIAL ACTIONS OF SEROTONIN ANTAGONISTS ON 2 BEHAVIORAL-MODELS OF SEROTONIN RECEPTOR ACTIVATION IN THE RAT1984
- Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PATNature, 1983
- 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition siteEuropean Journal of Pharmacology, 1983
- 8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activityJournal of Neural Transmission, 1982
- 8-Hydroxy-2-(dipropylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonistJournal of Medicinal Chemistry, 1981
- Elevating serotonin levels in brain with 5-hydroxytryptophan produces hypothermia in ratsPflügers Archiv - European Journal of Physiology, 1978