Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT
- 1 March 1985
- journal article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 61 (1-2), 131-135
- https://doi.org/10.1007/bf01253058
Abstract
The potent, centrally acting 5-HT receptor agonist 8-OH-DPAT was shown to induce a clearcut hypothermic response in naive and PCPA-pretreated conscious rats, maintained at 22 °C. PCPA pretreatment decreased the threshold dose of 8-OH-DPAT required to cause hypothermia, indicating that a sensitisation of 5-HT-receptor dependent mechanisms was involved. The results are discussed with reference to recent 5-HT receptor subclassification. It is suggested that body temperature measurements in the rat might provide a simplein vivo physiological means of studying central serotoninergic mechanisms, including 5-HT receptor sensitivity modification.Keywords
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