The use of intramolecular isotope effects to distinguish between deprotonation and hydrogen atom abstraction mechanisms in cytochrome P-450- and peroxidase-catalyzed N-demethylation reactions.
Open Access
- 1 December 1983
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 258 (23), 14445-14449
- https://doi.org/10.1016/s0021-9258(17)43882-8
Abstract
No abstract availableThis publication has 45 references indexed in Scilit:
- Source of oxygen in cytochrome P-450 catalyzed carbinolamine formationBiochemical and Biophysical Research Communications, 1982
- A novel P-450 model system for the N-dealkylation reactionJournal of the American Chemical Society, 1981
- The effect of alkaline denaturation on organic hydroperoxide-supported N-demethylase activities of catalase.CHEMICAL & PHARMACEUTICAL BULLETIN, 1981
- Mechanism of N-demethylation of aminopyrine by catalase-organic hydroperoxide systems.CHEMICAL & PHARMACEUTICAL BULLETIN, 1980
- Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediateBiochemical and Biophysical Research Communications, 1978
- Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450Biochemical and Biophysical Research Communications, 1977
- Moessbauer investigations of high-spin ferrous heme proteins. II. Chloroperoxidase, horseradish peroxidase, and hemoglobinBiochemistry, 1975
- Isotope effects in O- and N-demethylations mediated by rat liver microsomes: An application of direct insertion electron impact mass spectrometryChemico-Biological Interactions, 1974
- Moessbauer investigations of chloroperoxidase and its halide complexesBiochemistry, 1973
- The Mechanisms of Permanganate Oxidation. VIII. Substituted Benzylamines1Journal of the American Chemical Society, 1966